The aim of the paper is to show the multi-faceted interactions occurring between the phenomenon of technology transfer and cooperation existing along the knowledge-business axis. Research methods are the theoretical-empirical analysis, complemented with the study of subject literature, including reports and research done by the author. The study of the literature proved the correctness of the hypothesis that the cooperation between scientific units and various businesses is determined by the transfer of knowledge, aimed at implementing innovative solutions. Searching for facilitators and inhibitors in the process of knowledge transfer outside the theoretical domain reveals an enormous practical dimension in updating economic programs, on both the domestic and international level.