The aim of this research was an attempt at selecting areas suitable for economic activity in the Wieliczka district (powiat) that would meet specific exclusion criteria and then to carry out an analysis of their investment attractiveness. Economic activity in this study includes investment objects that could negatively impact the environment and human health. A spatial database consisted of 39 thematic layers divided into 12 groups. Digital maps were taken from the Digital Library of Małopolska. Spatial delimitation was carried out with the use of Geographic Information System (GIS) and the MapInfo Professional 8 software. The analysis allowed to choose two areas suitable for economic activity in the Gdów and Wieliczka municipalities. The results of the study suggest that economic activity can be located in the selected area because it equipped with rich investment infrastructure enhancing its attractiveness for investors.