Fragmentation efficiency is important concerned in mining and quarrying as it effects on the productivity of different mining operations. Various parameters effect on the quality of the fragmentation. However, this research was aimed to study the effect of powder factor, burden and spacing on the blasting fragmentation in the Djebel Bouzegza C01 quarry, Boumerdes, Algeria. For the evaluation of the average size fragment, it had been used the processing image Split Desktop (P50) and compared with the results of the predictive model Kuz Ram (X50). The highest values of X50 (680.00 mm) and P50 (645.45 mm) were recorded when the largest values of (burden × spacing) that were (4.5 m × 4.5 m) and in the smallest value of the powder factor which was 0.20 kg · m–3. The Fragmentation Indicator FI gives the affectedness of the Kuz Ram Model. After plotting the results on 3D surface, it has improved the results of the average size when the burden will be less than 3.70 m and the powder factor will be less than 0.64 kg · m–3 while to minimized the percentile of oversize fragments, it was obtained that the burden will be less than 3.70 mm, otherwise the powder factor was more than 0.30 kg · m–3. Blast design parameters and the powder factor are therefore important variables in improving the results of blast fragmentation.