The Sahara’s Nememcha mountains chain suffers from a significant lack of large-scale geological information. In the Bir Later region with complex morpho-structural settings and arid climate conditions; geological maps have not been yet completed by competent authorities. However, this region harbours Algeria’s largest phosphate mine; with its reserves estimated at more than one billion tons of ore grading 20% phosphorus pentoxide. Geomatic-based techniques of Multi-source Remote Sensing data allow the classification and identification of the lithologic features. The adopted method quarries the spectral signal, the alteration processes, and the thickness of the rocky banks. For this task, we apply Principal Component Analysis (PCA), Minimum Noise Fraction (MNF), directional filters, and unsupervised classification (K-Means data) techniques to calibrate and correct Landsat 8 OLI and Sentinel-2A multispectral images. A petrographic study with field and laboratory work was carried out in order to confirm the machine description of the different facies. The results showed that the proposed lithology classification scheme can achieve accurate classification of all lithologic types, in the Cenozoic, Mesozoic, and Holocene deposits of the study area. The lithological map obtained from the GIS-RS-Processing is highly correlated with our field survey. Therefore, multispectral image data (Landsat 8 OLI and Sentinel-2A) coupled with an advanced image enhancement technique and field surveys are recommended as a rapid and cost-effective tool for lithologic discrimination and mapping. The experimental results fully demonstrated the advantages of the reliance on laboratory tests in the sensed lithology validation in an arid area.